Cancer stem cells--an old idea that's new again: implications for the diagnosis and treatment of breast cancer.

@article{Song2007CancerSC,
  title={Cancer stem cells--an old idea that's new again: implications for the diagnosis and treatment of breast cancer.},
  author={Lynda Li Song and Lucio Miele},
  journal={Expert opinion on biological therapy},
  year={2007},
  volume={7 4},
  pages={431-8}
}
The medical treatment of solid tumors is beset by two fundamental problems: the fact that even striking initial responses are often followed by drug-resistant recurrences, and the lack of predictive tools to design individualized treatment strategies. These therapeutic problems have a biological basis in the genetic heterogeneity and genomic instability of solid tumors. Traditionally, these were thought to result from accumulated mutations in random tissue cells, leading first to transformation… CONTINUE READING