Cancer stem cells: the ‘heartbeat’ of gastric cancer

  title={Cancer stem cells: the ‘heartbeat’ of gastric cancer},
  author={Guihua Xu and Jie Shen and Xiaohui Yang and Masakiyo Sasahara and Xiulan Su},
  journal={Journal of Gastroenterology},
Gastric cancer (GC) remains one of the most common cancers worldwide. Its prevalence is still on the rise in the developing countries due to the ageing population. The cancer stem cell (CSC) theory provides a new insight into the interpretation of tumor initiation, aggressive growth, recurrence, and metastasis of cancer, as well as the development of new strategies for cancer treatment. This review will focus on the progress of biomarkers and signaling pathways of CSCs, the complex crosstalk… CONTINUE READING