Cancer stem cells: models and concepts.

@article{Dalerba2007CancerSC,
  title={Cancer stem cells: models and concepts.},
  author={Piero Dalerba and Robert W. Cho and Michael F. Clarke},
  journal={Annual review of medicine},
  year={2007},
  volume={58},
  pages={267-84}
}
Although monoclonal in origin, most tumors appear to contain a heterogeneous population of cancer cells. This observation is traditionally explained by postulating variations in tumor microenvironment and coexistence of multiple genetic subclones, created by progressive and divergent accumulation of independent somatic mutations. An additional explanation, however, envisages human tumors not as mere monoclonal expansions of transformed cells, but rather as complex tridimensional tissues where… CONTINUE READING
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