Cancer stem cells: impact, heterogeneity, and uncertainty.

@article{Magee2012CancerSC,
  title={Cancer stem cells: impact, heterogeneity, and uncertainty.},
  author={Jeffrey A. Magee and Elena Piskounova and Sean J Morrison},
  journal={Cancer cell},
  year={2012},
  volume={21 3},
  pages={
          283-96
        }
}
The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers heterogeneity to some cancers beyond that explained by clonal evolution or environmental differences. In such cancers, functional differences between tumorigenic and nontumorigenic cells influence response to therapy and prognosis. However, it remains uncertain whether the model applies to many, or few, cancers due to questions about the robustness of cancer stem cell markers and the extent to which… CONTINUE READING
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