Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance.

@article{Gangemi2009CancerSC,
  title={Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance.},
  author={Rosaria Maria Rita Gangemi and Laura Paleari and Anna Maria Orengo and Alfredo Cesario and Leonardo Chessa and Silvano Ferrini and Patrizia Russo},
  journal={Current medicinal chemistry},
  year={2009},
  volume={16 14},
  pages={
          1688-703
        }
}
Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to their expression of various membrane transporter molecules (such as MDR-1), detoxifying enzymes and DNA repair proteins. In addition, they also have a slow rate of cell turnover and therefore escape from chemotherapeutic agents that target rapidly replicating cells. Cancer stem cells (CSC), being the mutated counterparts of normal SC, also have similar properties, which allow them to survive therapy. These… CONTINUE READING

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