Cancer stem cells: The challenges ahead

@article{Medema2013CancerSC,
  title={Cancer stem cells: The challenges ahead},
  author={Jan Paul Medema},
  journal={Nature Cell Biology},
  year={2013},
  volume={15},
  pages={338-344}
}
Cancer stem cells (CSCs) have been proposed as the driving force of tumorigenesis and the seeds of metastases. However, their existence and role remain a topic of intense debate. Recently, the identification of CSCs in endogenously developing mouse tumours has provided further support for this concept. Here I discuss the challenges in identifying CSCs, their dependency on a supportive niche and their role in metastasis, and propose that stemness is a flexible — rather than fixed — quality of… CONTINUE READING
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