Cancer stem cells: AMLs show the way.

  title={Cancer stem cells: AMLs show the way.},
  author={Dominique Bonnet},
  journal={Biochemical Society transactions},
  volume={33 Pt 6},
The blood-related cancer leukaemia was the first disease where human CSCs (cancer stem cells), or LSCs (leukaemic stem cells), were isolated. The haematopoietic system is one of the best tissues for investigating CSCs, since the developmental hierarchy of normal blood formation is well defined. Leukaemia can now be viewed as aberrant haematopoietic processes initiated by rare LSCs that have maintained or reacquired the capacity for indefinite proliferation through accumulated mutations and/or… CONTINUE READING

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