Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: potential role of hypoxia.

@article{MarieEgyptienne2013CancerSC,
  title={Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: potential role of hypoxia.},
  author={Delphine Tamara Marie-Egyptienne and Ines Lohse and Richard Peter Hill},
  journal={Cancer letters},
  year={2013},
  volume={341 1},
  pages={63-72}
}
Numerous studies have demonstrated the presence of cancer stem cells (CSCs) within solid tumors. Although the precursor of these cells is not clearly established, recent studies suggest that the phenotype of CSCs may be quite plastic and associated with the epithelial-to-mesenchymal transition (EMT). In patients, the presence of EMT and CSCs has been implicated in increased resistance to radiotherapy. Hypoxia, a negative prognostic factor for treatment success, is a potent driver of a multitude… CONTINUE READING
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