Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective.

@article{Atlasi2014CancerSC,
  title={Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective.},
  author={Yaser Atlasi and Leendert H J Looijenga and Riccardo Fodde},
  journal={Current topics in developmental biology},
  year={2014},
  volume={107},
  pages={
          373-404
        }
}
Cancer stem cells (CSCs) are thought to represent the "beating heart" of malignant growth as they continuously fuel tumors through their ability to self-renew and differentiate. Moreover, they are also believed to underlie malignant behavior, local invasion, and metastasis in distal organ sites upon reversible epithelial-to-mesenchymal transitions (EMTs). Nevertheless, the CSC concept has been the object of controversy, mainly due to the absence of robust operational definitions and to the lack… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-6 of 6 extracted citations