Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells

@inproceedings{Lu2015CancerSC,
  title={Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells},
  author={Lin Lu and Huimin Tao and Alfred E. Chang and Yangyang Hu and Guoshun Shu and Quanning Chen and Martin U Egenti and John F. Owen and Jeffrey S. Moyer and Mark EP Prince and Shiang Huang and Max S. Wicha and Jian-Chuan Xia and Qiao Li},
  booktitle={Oncoimmunology},
  year={2015}
}
The inability to target cancer stem cells (CSC) may be a significant factor contributing to treatment failure. We have developed a strategy to target the CSC populations in melanoma and squamous cell carcinoma using CSC lysate-pulsed dendritic cells (DCs). The CSC-DC vaccine was administered in the adjuvant setting after localized radiation therapy of established tumors. Using mouse models we demonstrated that DCs pulsed with CSCs enriched by virtue of their expression of the CSC marker ALDH… CONTINUE READING
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