Cancer stem cell targeting using the alpha-particle emitter, 213Bi: mathematical modeling and feasibility analysis.

@article{Sgouros2008CancerSC,
  title={Cancer stem cell targeting using the alpha-particle emitter, 213Bi: mathematical modeling and feasibility analysis.},
  author={G. Sgouros and Hong Mei Song},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={2008},
  volume={23 1},
  pages={74-81}
}
There is increasing recognition that treatment failure in cancer may be associated with the failure to sterilize a small subpopulation of tumor cells that have been characterized as tumor stem cells. Defined as cells that are able to self-renew and also to replenish a phenotypically diverse tumor-cell population, such cells are also considered resistant to chemotherapy. These characteristics are optimal for targeting by using alpha-particle-emitting radionuclides. Because of their high-energy… CONTINUE READING
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