Cancer stem cell-directed therapies: recent data from the laboratory and clinic.

@article{Park2009CancerSC,
  title={Cancer stem cell-directed therapies: recent data from the laboratory and clinic.},
  author={Christopher Y Park and Diane Tseng and Irving L Weissman},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2009},
  volume={17 2},
  pages={219-30}
}
Cancer stem cells (CSCs) are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted into immunodeficient mouse hosts, and (ii) self-renew, demonstrated by their ability to be serially transplanted. These properties suggest that CSCs are required for tumor maintenance and metastasis; thus, it has been predicted that CSC elimination is required for cure. This prediction has profoundly altered paradigms for cancer research, compelling investigators to… CONTINUE READING