Cancer stem cell characteristics in retinoblastoma.

  title={Cancer stem cell characteristics in retinoblastoma.},
  author={Gail M Seigel and Lorrie M. Campbell and Malathi Narayan and F Gonzalez-fernandez},
  journal={Molecular vision},
PURPOSE There is increasing evidence that cancer stem cells contribute to tumor progression and chemoresistance in a variety of malignancies, including brain tumors, leukemias, and breast carcinomas. In this study, we tested the hypothesis that retinoblastomas contain subpopulations of cells that exhibit cancer stem cell properties. METHODS The following sources of retinoblastoma cells and tissues were examined for the presence of stem cell markers by immunocytochemistry: retinoblastoma… CONTINUE READING