Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

  title={Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.},
  author={Koshi Mimori and Teresa Druck and Hirokazu Inoue and Hansjuerg Alder and Lori Berk and Masaki Mori and Kay F Huebner and Carlo M. Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 13},
We have sequenced 870 kilobases of the FHIT/FRA3B locus, from FHIT intron 3 to intron 7. The locus is AT rich (61.5%) and Alu poor (6. 2%), and it apparently does not harbor other genes. In a detailed analysis of the 308-kilobase region between FHIT exon 5 and the telomeric end of intron 3, a region known to encompass a human papillomavirus-16 integration site and two clusters of aphidicolin-induced chromosome 3p14.2 breakpoints, we have precisely mapped 10 deletion and translocation endpoints… CONTINUE READING


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Mimori et al

Y. Segal, B. Peissel, +6 authors 62–69. Medical Sciences
Proc. Natl. Acad. Sci. USA 96 • 1999
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