Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation.

@article{2017CancerselectiveDO,
  title={Cancer-selective death of human breast cancer cells by leelamine is mediated by bax and bak activation.},
  author={},
  journal={Molecular carcinogenesis},
  year={2017},
  volume={56 2},
  pages={
          337-348
        }
}
    The present study is the first to report inhibition of breast cancer cell growth in vitro and in vivo and suppression of self-renewal of breast cancer stem cells (bCSC) by a pine bark component (leelamine). Except for a few recent publications in melanoma, anticancer pharmacology of this interesting phytochemical is largely elusive. Leelamine (LLM) dose-dependently inhibited viability of MDA-MB-231 (triple-negative), MCF-7 (estrogen receptor-positive), and SUM159 (triple-negative) human breast… CONTINUE READING