Cancer risks and immunohistochemical profiles linked to the Danish MLH1 Lynch syndrome founder mutation

Abstract

Founder mutations with a large impact in distinct populations have been described in Lynch syndrome. In Denmark, the MLH1 c.1667+2_1667_+8TAAATCAdelinsATTT mutation accounts for 25 % of the MLH1 mutant families. We used the national Danish hereditary nonpolyposis colorectal cancer register to estimate the cumulative lifetime risks for Lynch syndrome… (More)
DOI: 10.1007/s10689-012-9552-4

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