Cancer risk in systemic lupus: an updated international multi-centre cohort study.

  title={Cancer risk in systemic lupus: an updated international multi-centre cohort study.},
  author={Sasha Bernatsky and Rosalind Ramsey-Goldman and Jeremy Labrecque and Lawrence Joseph and Jean-François Boivin and Michelle Petri and Asad A Zoma and Susan Manzi and Murray B. Urowitz and Dafna D Gladman and Paul R Fortin and Ellen M. Ginzler and Edward H. Yelin and S -C Bae and Daniel Wallace and S. M. Edworthy and S. C. Jacobsen and Caroline Gordon and Mary Anne Dooley and Christine A Peschken and John G. Hanly and Graciela S Alarc{\'o}n and Ola Nived and Guillermo Ruiz-Irastorza and David Alan Isenberg and Anisur Rahman and Torsten Witte and Cynthia Aranow and Diane L. Kamen and Kristj{\'a}n Steinsson and Anca Dinu Askanase and Susan G. Barr and Lindsey A. Criswell and Gunnar K Sturfelt and Neha M Patel and Jean-Luc Sen{\'e}cal and Michel Zummer and Janet Elizabeth Pope and Stephanie Ensworth and Hani D El-Gabalawy and Timothy L. McCarthy and Lene Dreyer and J. Sibley and Yvan St Pierre and Ann Elaine Clarke},
  journal={Journal of autoimmunity},
OBJECTIVE To update estimates of cancer risk in SLE relative to the general population. METHODS A multisite international SLE cohort was linked with regional tumor registries. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers. RESULTS Across 30 centres, 16,409 patients were observed for 121,283 (average 7.4) person-years. In total, 644 cancers occurred. Some cancers, notably hematologic malignancies, were substantially increased (SIR 3.02, 95… CONTINUE READING
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