Cancer risk in mutation carriers of DNA-mismatch-repair genes.

  title={Cancer risk in mutation carriers of DNA-mismatch-repair genes.},
  author={Markku T Aarnio and Risto Sankila and Eero I Pukkala and Reijo Salovaara and Lauri A. Aaltonen and Albert de la Chapelle and P{\"a}ivi Peltom{\"a}ki and J. P. Mecklin and Heikki J{\"a}rvinen},
  journal={International journal of cancer},
  volume={81 2},
Excessive incidence of various cancers is a challenging feature of the hereditary-non-polyposis-colorectal-cancer (HNPCC) syndrome. This study estimated the cancer incidences in HNPCC compared with the general population. Individuals in a cohort of 1763 members of 50 genetically diagnosed families were categorized according to their genetic status as mutation carriers, non-carriers, or individuals at 50 or 25% risk of being a carrier. Incidences of cancers in these groups were compared with… CONTINUE READING
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