Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research

  title={Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research},
  author={Eric A. Engels},
  journal={Expert Review of Vaccines},
  pages={197 - 206}
  • E. Engels
  • Published 1 April 2005
  • Medicine, Biology
  • Expert Review of Vaccines
Simian virus (SV)40 was an accidental contaminant of poliovirus vaccines used widely in the USA and other countries in 1955–1962. Exposure to SV40 via contaminated vaccines has led to concern as SV40 causes cancer in laboratory animals. In addition, some laboratories, although not all, have detected SV40 DNA in human tumors including mesothelioma, certain brain tumors, osteosarcoma and non-Hodgkin’s lymphoma. This article reviews the data regarding contamination of poliovirus vaccines with SV40… 
Is there a role for SV40 in human cancer?
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There is inadequate evidence to support widespread SV40 infection in the population, increased tumor incidence in those individuals who received contaminated vaccine, or a direct role for SV40 in human cancer.
Absence of SV40 antibodies or DNA fragments in prediagnostic mesothelioma serum samples
No significant association between SV40 antibody response in prediagnostic sera and risk of mesothelioma was seen and although some sera could neutralize SV40, preabsorption with BKV and JCV VP1 showed that this neutralizing activity was due to cross‐reacting antibodies and did not represent truly SV40‐specific antibodies.
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Cancer incidence in Denmark following exposure to poliovirus vaccine contaminated with simian virus 40.
Exposure to SV40-contaminated poliovirus vaccine in Denmark was not associated with increased cancer incidence and incidence of mesothelioma, ependymoma, choroid plexus tumor, or non-Hodgkin's lymphoma.
Thirty-five year mortality following receipt of SV40- contaminated polio vaccine during the neonatal period
The results are, for the most part, consistent with other negative epidemiologic investigations of risks from SV40-contaminated vaccines, and further study of testicular cancer may be warranted, and it will be important to continue monitoring this cohort which is now reaching middle-age.
Contamination of poliovirus vaccines with simian virus 40 (1955-1963) and subsequent cancer rates.
After more than 30 years of follow-up, exposure to SV40-contaminated poliovirus vaccine was not associated with significantly increased rates of ependymomas and other brain cancers, osteosarcomas, or mesotheliomas in the United States.
Case-control study of cancer among US Army veterans exposed to simian virus 40-contaminated adenovirus vaccine.
Findings do not support a role for SV40 in the development of brain tumors, mesothelioma, and non-Hodgkin's lymphoma, including a parenteral adenovirus vaccine given to several hundred thousand US military recruits.
An evaluation of the carcinogenicity of simian virus 40 in man.
It appears that the largest source of potentialhuman infectivity by SV40 in the US was formalinized poliomyelitis vaccine containing the simian agent administered subcutaneously.
Childhood exposure to simian virus 40‐contaminated poliovirus vaccine and risk of AIDS‐associated non‐Hodgkin's lymphoma
It is concluded that childhood exposure to SV40 through receipt of contaminated poliovirus vaccine was not associated with increased risk for AIDS‐associated NHL, and a role for SV40 in lymphomagenesis among immunosuppressed persons is not supported.
Lack of serologic evidence for prevalent simian virus 40 infection in humans.
Screening human sera for antibodies to SV40 using direct and competitive enzyme-linked immunosorbent assays indicate that some individuals have BKV and/or JCV antibodies that cross-react with SV40, but they do not provide support for SV40 being a prevalent human pathogen.
Case-control study of simian virus 40 and non-Hodgkin lymphoma in the United States.
In persons born before 1963, the presence of SV40-specific antibodies, although rare, could reflect exposure to SV40 -contaminated vaccines and NHL risk was unrelated to serologic evidence of SV 40 exposure or infection.
Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccines.
Age-specific trends in U.S. pleural mesothelioma incidence rates are not consistent with an effect of exposure to SV40-contaminated poliovirus vaccine, and monitoring of vaccine-exposed cohorts should continue.
Simian virus 40 (SV40) and human cancer: a review of the serological data
Serological data do not support the possibility that SV40 is circulating in human communities or that it is associated with human cancer.