Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research

@article{Engels2005CancerRA,
  title={Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research},
  author={E. Engels},
  journal={Expert Review of Vaccines},
  year={2005},
  volume={4},
  pages={197 - 206}
}
  • E. Engels
  • Published 2005
  • Biology, Medicine
  • Expert Review of Vaccines
Simian virus (SV)40 was an accidental contaminant of poliovirus vaccines used widely in the USA and other countries in 1955–1962. Exposure to SV40 via contaminated vaccines has led to concern as SV40 causes cancer in laboratory animals. In addition, some laboratories, although not all, have detected SV40 DNA in human tumors including mesothelioma, certain brain tumors, osteosarcoma and non-Hodgkin’s lymphoma. This article reviews the data regarding contamination of poliovirus vaccines with SV40… Expand
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References

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TLDR
Exposure to SV40-contaminated poliovirus vaccine in Denmark was not associated with increased cancer incidence and incidence of mesothelioma, ependymoma, choroid plexus tumor, or non-Hodgkin's lymphoma. Expand
Thirty-five year mortality following receipt of SV40- contaminated polio vaccine during the neonatal period
TLDR
The results are, for the most part, consistent with other negative epidemiologic investigations of risks from SV40-contaminated vaccines, and further study of testicular cancer may be warranted, and it will be important to continue monitoring this cohort which is now reaching middle-age. Expand
Contamination of poliovirus vaccines with simian virus 40 (1955-1963) and subsequent cancer rates.
TLDR
After more than 30 years of follow-up, exposure to SV40-contaminated poliovirus vaccine was not associated with significantly increased rates of ependymomas and other brain cancers, osteosarcomas, or mesotheliomas in the United States. Expand
Case-control study of cancer among US Army veterans exposed to simian virus 40-contaminated adenovirus vaccine.
TLDR
Findings do not support a role for SV40 in the development of brain tumors, mesothelioma, and non-Hodgkin's lymphoma, including a parenteral adenovirus vaccine given to several hundred thousand US military recruits. Expand
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TLDR
It appears that the largest source of potentialhuman infectivity by SV40 in the US was formalinized poliomyelitis vaccine containing the simian agent administered subcutaneously. Expand
Childhood exposure to simian virus 40‐contaminated poliovirus vaccine and risk of AIDS‐associated non‐Hodgkin's lymphoma
TLDR
It is concluded that childhood exposure to SV40 through receipt of contaminated poliovirus vaccine was not associated with increased risk for AIDS‐associated NHL, and a role for SV40 in lymphomagenesis among immunosuppressed persons is not supported. Expand
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TLDR
Screening human sera for antibodies to SV40 using direct and competitive enzyme-linked immunosorbent assays indicate that some individuals have BKV and/or JCV antibodies that cross-react with SV40, but they do not provide support for SV40 being a prevalent human pathogen. Expand
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TLDR
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Trends in U.S. pleural mesothelioma incidence rates following simian virus 40 contamination of early poliovirus vaccines.
TLDR
Age-specific trends in U.S. pleural mesothelioma incidence rates are not consistent with an effect of exposure to SV40-contaminated poliovirus vaccine, and monitoring of vaccine-exposed cohorts should continue. Expand
Simian virus 40 (SV40) and human cancer: a review of the serological data
TLDR
Serological data do not support the possibility that SV40 is circulating in human communities or that it is associated with human cancer. Expand
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