Cancer risk assessment for health care workers occupationally exposed to cyclophosphamide.

@article{Sessink1995CancerRA,
  title={Cancer risk assessment for health care workers occupationally exposed to cyclophosphamide.},
  author={Paul J. M. Sessink and E. Dinant Kroese and Henk J van Kranen and R. P. Bos},
  journal={International archives of occupational and environmental health},
  year={1995},
  volume={67 5},
  pages={317-23}
}
In the present study a cancer risk assessment of occupational exposure to cyclophosphamide (CP), a genotoxic carcinogenic antineoplastic agent, was carried out following two approaches based on (1) data from an animal study and (2) data on primary and secondary tumors in CP-treated patients. Data on the urinary excretion of CP in health care workers were used to estimate the uptake of CP, which ranged from 3.6 to 18 micrograms/day. Based on data from an animal study, cancer risks were… CONTINUE READING