Cancer-related mutations in BRCA1-BRCT cause long-range structural changes in protein-protein binding sites: a molecular dynamics study.


Cancer-associated mutations in the BRCT domain of BRCA1 (BRCA1-BRCT) abolish its tumor suppressor function by disrupting interactions with other proteins such as BACH1. Many cancer-related mutations do not cause sufficient destabilization to lead to global unfolding under physiological conditions, and thus abrogation of function probably is due to localized… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.


Citations per Year

179 Citations

Semantic Scholar estimates that this publication has 179 citations based on the available data.

See our FAQ for additional information.