Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer

Abstract

BACKGROUND Cancer-related immune antigens in the tumor microenvironment could represent an obstacle to agents targeting EGFR "cetuximab" or VEGF "bevacizumab" in metastatic colorectal cancer (mCRC) patients. METHODS Infiltrating immune cells into tumor tissues, cancer-related expression of immune antigens (CD3, CD8, CD68, CD73, MPO, CD15/FUT4) from 102… (More)
DOI: 10.1186/s13046-015-0225-7

6 Figures and Tables

Topics

Statistics

0204020162017
Citations per Year

Citation Velocity: 23

Averaging 23 citations per year over the last 2 years.

Learn more about how we calculate this metric in our FAQ.
  • Presentations referencing similar topics