Cancer promoted by the oncoprotein v-ErbA may be due to subcellular mislocalization of nuclear receptors.

@article{Bonamy2005CancerPB,
  title={Cancer promoted by the oncoprotein v-ErbA may be due to subcellular mislocalization of nuclear receptors.},
  author={Ghislain M C Bonamy and Anne Guiochon-Mantel and Lizabeth A. Allison},
  journal={Molecular endocrinology},
  year={2005},
  volume={19 5},
  pages={1213-30}
}
The retroviral v-ErbA oncoprotein is a highly mutated variant of the thyroid hormone receptor alpha (TRalpha), which is unable to bind T(3) and interferes with the action of TRalpha in mammalian and avian cancer cells. v-ErbA dominant-negative activity is attributed to competition with TRalpha for T(3)-responsive DNA elements and/or auxiliary factors involved in the transcriptional regulation of T(3)-responsive genes. However, competition models do not address the altered subcellular… CONTINUE READING