Cancer progression by non‐clonal chromosome aberrations

@article{Heng2006CancerPB,
  title={Cancer progression by non‐clonal chromosome aberrations},
  author={Henry H. Q. Heng and Steven W. Bremer and Joshua B. Stevens and Karen J. Ye and Fred R. Miller and Gou Liu and Christine J. Ye},
  journal={Journal of Cellular Biochemistry},
  year={2006},
  volume={98}
}
The establishment of the correct conceptual framework is vital to any scientific discipline including cancer research. Influenced by hematologic cancer studies, the current cancer concept focuses on the stepwise patterns of progression as defined by specific recurrent genetic aberrations. This concept has faced a tough challenge as the majority of cancer cases follow non‐linear patterns and display stochastic progression. In light of the recent discovery that genomic instability is directly… 

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