Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb).

@article{Jeong2007CancerpreventivePL,
  title={Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb).},
  author={Jin Boo Jeong and Hyung Jin Jeong and Jae Ho Park and Sun Hee Lee and Jeong Rak Lee and Hee Kyeong Lee and Gyu Young Chung and Jeong Doo Choi and Ben O. de Lumen},
  journal={Journal of agricultural and food chemistry},
  year={2007},
  volume={55 26},
  pages={10707-13}
}
Lunasin, a unique 43 amino acid, 4.8 kDa cancer-chemopreventive peptide initially reported in soybean and now found in barley and wheat, has been shown to be cancer-chemopreventive in mammalian cells and in a skin cancer mouse model against oncogenes and chemical carcinogens. To identify bioactive components in traditional herbal medicines and in search for new sources of lunasin, we report here the properties of lunasin from Solanum nigrum L. (SNL), a plant indigenous to northeast Asia… CONTINUE READING