Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.

@article{Mi2009CancerPI,
  title={Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.},
  author={Lixin Mi and Nanqin Gan and Amrita K. Cheema and Sivanesan Dakshanamurthy and Xiantao Wang and David C. Yang and Fung-Lung Chung},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 25},
  pages={17039-51}
}
Although it is conceivable that cancer preventive isothiocyanates (ITCs), a family of compounds in cruciferous vegetables, induce cell cycle arrest and apoptosis through a mechanism involving oxidative stress, our study shows that binding to cellular proteins correlates with their potencies of apoptosis induction. More recently, we showed that ITCs bind selectively to tubulins. The differential binding affinities toward tubulin among benzyl isothiocyanate, phenethyl isothiocyanate, and… CONTINUE READING

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1 Excerpt

unpublished results. SCHEME 1. Proposed mechanism of ITC-induced tubulin degradation. ITCs Induce Tubulin Degradation 17050 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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