Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.

@article{Murakami2006CancerpreventiveAT,
  title={Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells.},
  author={Akira Murakami and Hajime Ohigashi},
  journal={Biological chemistry},
  year={2006},
  volume={387 4},
  pages={387-92}
}
Active inflammatory leukocytes are a major endogenous source of reactive oxygen and nitrogen oxide species (RONS). We have recently established novel bioassay systems, in which either phorbol ester-stimulated, differentiated HL-60 human leukemia cells or lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages were co-cultured with AS52 Chinese hamster ovary cells. Extensive screening of extracts from Asian vegetables and fruits led to the identification of 1'-acetoxychavicol acetate… CONTINUE READING

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