Cancer predisposition caused by elevated mitotic recombination in Bloom mice

  title={Cancer predisposition caused by elevated mitotic recombination in Bloom mice},
  author={Guangbin Luo and Irma M. Santoro and Lisa D. McDaniel and Ichiko Nishijima and Michael Mills and Hagop Youssoufian and Hannes Vogel and Roger A. Schultz and Allan Bradley},
  journal={Nature Genetics},
Bloom syndrome is a disorder associated with genomic instability that causes affected people to be prone to cancer. Bloom cell lines show increased sister chromatid exchange, yet are proficient in the repair of various DNA lesions. The underlying cause of this disease are mutations in a gene encoding a RECQ DNA helicase. Using embryonic stem cell technology, we have generated viable Bloom mice that are prone to a wide variety of cancers. Cell lines from these mice show elevations in the rates… CONTINUE READING
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a proposed role for RecQ family helicases

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comparison with the Werner’s syndrome helicase

  • V. Gharibyan, Youssoufian, H. Localization of the Bloom’s syndrome helicase to p structures, the nuclear matrix, regulation during the cell cycle
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