Cancer permeates locally within ontogenetic compartments: clinical evidence and implications for cancer surgery.

@article{Hckel2012CancerPL,
  title={Cancer permeates locally within ontogenetic compartments: clinical evidence and implications for cancer surgery.},
  author={Michael H{\"o}ckel},
  journal={Future oncology},
  year={2012},
  volume={8 1},
  pages={29-36}
}
The pathophysiologic process of local tumor spread is regarded as an isotropic infiltration of microscopic extensions of the malignant lesion irrespective of tissue boundaries. By contrast, the ontogenetic compartment theory states that malignant solid tumors are locally confined, for a relatively long phase during their natural course, to a permissive compartment derived from a common primordium in embryonic development. Tumor permeation is isotropic within the permissive ontogenetic… CONTINUE READING

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a prospective ana lysis

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Resection of the embryologically defined uterovaginal ( Müllerian ) compartment and pelvic control in patients with cervical cancer : a prospective ana lysis

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