Cancer of unknown primary site: still an entity, a biological mystery and a metastatic model

  title={Cancer of unknown primary site: still an entity, a biological mystery and a metastatic model},
  author={Frank Anthony Greco},
  journal={Nature Reviews Cancer},
Cancer of unknown primary site (CUP) has frustrated patients, their families and physicians for decades because appropriate therapies for patients with metastatic cancers are determined by the primary site or the tissue of origin. Now that we have methods to identify the tissue of origin for the majority of these patients, additional clinical and biological questions are being asked and addressed. 
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