Cancer of unknown primary (CUP): does cause of death and family history implicate hidden phenotypically changed primaries?

@article{Hemminki2012CancerOU,
  title={Cancer of unknown primary (CUP): does cause of death and family history implicate hidden phenotypically changed primaries?},
  author={Kari Hemminki and Melanie Bevier and Jan Sundquist and Akseli Hemminki},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2012},
  volume={23 10},
  pages={2720-4}
}
BACKGROUND Cancer of unknown primary (CUP) is diagnosed at the metastatic stage. We aimed to identify hidden primary cancers in CUP patients by comparison with cancers in family members. We take use of the fact that the cause of death in CUP patients is often coded as the cancer in the organ of fatal metastasis. PATIENTS AND METHODS Forty-one thousand five hundred and twenty-three CUP patients were identified in the Swedish Family-Cancer Database, and relative risks (RRs) were calculated for… CONTINUE READING