Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols

  title={Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols},
  author={Rodolfo Saracci and Manolis Kogevinas and Regina Winkelmann and Pier Alberto Bertazzi and Bueno de Mesquita and D. Coggon and Lois M Green and T P Kauppinen and K. A. L'abb{\'e} and Margareta Littorin and Elsebeth Lynge and John Duncan Mathews and Manfred Neuberger and John Osman and Neil Pearce},
  journal={The Lancet},

Cancer incidence and mortality in women occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins

Mortality and cancer incidence in an international cohort of 701 women from an International Register of Workers occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins is examined and results on cancer mortality were consistent with those on incidence.

Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study.

Exposure to herbicides contaminated with TCDD and higher chlorinated dioxins may be associated with a small increase in overall cancer risk and in risk for specific cancers.

Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins

Results are consistent with results from other cohorts which showed an increased overall cancer mortality and mortality of respiratory cancer after long-term exposure to these phenoxy herbicides and dioxins.

Mortality and cancer morbidity of Finnish chlorophenoxy herbicide applicators: an 18-year prospective follow-up.

The study does not support the contention that spraying of 2,4-D and2,4,5-T containing herbicides carries any significant risk of cancer, and the medium to low statistical power of the studydoes not allow any far reaching negative conclusions regarding the carcinogenicity of the agents.

Mortality and cancer incidence among sawmill workers exposed to chlorophenate wood preservatives.

The results of this study are consistent with the borderline positive associations seen in other recently reported studies of chlorophenate-exposed workforces.

Dioxin exposure and non-malignant health effects: a mortality study.

These results, although not conclusive, concur with previous data in suggesting cardiopulmonary and endocrine effects in humans highly exposed to TCDD, as well as its complex interaction with the endocrine system.

Persistent health effects of dioxin contamination in herbicide production.

The prevalence of neurological symptoms and signs of chronic liver disease were related to TCDD in blood and abnormal poryphyrins in urine, contributing to the evidence that chloracne is not the only chronic disease which can be related toTCDD exposure, even 23 years after exposure and despite high intersubject variability of T CDD half-life and other exposures.

Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers.

The authors studied noncancer mortality among phenoxyacid herbicide and chlorophenol production workers and sprayers included in an international study comprising 36 cohorts from 12 countries followed from 1939 to 1992 to suggest a moderate healthy worker effect for all circulatory diseases, especially ischemic heart disease.

Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

The study highlights the wide range of cancer rates and the lack of consistency across dioxin studies and found no coherent evidence of increased cancer risk from dioxIn exposure in this cohort of male chemical production workers.



Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

This study of mortality among workers with occupational exposure to TCDD does not confirm the high relative risks reported for many cancers in previous studies, and conclusions about an increase in the risk of soft-tissue sarcoma are limited by small numbers and misclassification on death certificates.

Mortality and incidence of cancer at four factories making phenoxy herbicides.

Four British cohorts of chemical manufacturers recruited to the survey of workers exposed to these compounds in their production or use are described, and their mortality compared with that in the national population is described.

Mortality of workers exposed to 2 methyl-4 chlorophenoxyacetic acid.

The findings suggest that any risk of soft tissue sarcoma is less than that indicated by earlier studies of 2,4,5-T (2,4-5-trichlorophenoxyacetic acid) and 2,3,3-trishlorophenol and is small in absolute terms.

Cause specific mortality among employees engaged in the manufacture, formulation, or packaging of 2,4-dichlorophenoxyacetic acid and related salts.

Analysis by production area, duration of exposure, and cumulative dose showed no patterns suggestive of a causal association between 2,4-D exposure and any other particular cause of death, and the absence of an increased risk of brain cancer in people exposed to 2, 4-D is supported.

A cohort mortality study of forestry workers exposed to phenoxy acid herbicides.

  • L. Green
  • Medicine
    British journal of industrial medicine
  • 1991
A cohort mortality study was undertaken of forestry workers at a public electrical utility who had worked for six months or more during 1950-82 and who were routinely exposed to herbicides including phenoxy acids, finding no excess mortality was found in this cohort relative to the reference population.

A follow-up study of cancer incidence among workers in manufacture of phenoxy herbicides in Denmark.

  • E. Lynge
  • Medicine
    British Journal of Cancer
  • 1985
The Swedish observation of an increased risk of STS following exposure to phenoxy herbicides unlikely to be contaminated with 2,3,7,8-TCDD supported, but several potential biases have to be taken into account in interpretation of this observation and these are discussed.

Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand.

The discovery of cases in trichlorophenol manufacturing plants in the United States lended support to Swedish findings, but further studies are needed to conclude whether human exposure to these chemicals truly increases the risk of soft tissue sarcoma.

Phenoxy herbicides and soft-tissue sarcomas in female rice weeders. A population-based case-referent study.

A population-based case-referent study was conducted in an area of northern Italy where rice growing is the predominant agricultural activity and phenoxy herbicides have been used since 1950, finding the relative risk of adverse events among women exposed to chemical herbicides increased when attention was restricted to women exposed in the whole 1950-1955 period and to younger age groups.

Exposure to dioxins as a risk factor for soft tissue sarcoma: a population-based case-control study.

In a case-control study including 237 cases with soft tissue sarcoma and 237 controls, previous jobs and exposures to different agents, including pesticides, were assessed. Exposure to phenoxyacetic