Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos.

Abstract

The objective of this analysis was the estimation of the cancer risks of asbestos and asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 asbestos workers was selected for high-resolution computer tomography of the chest in 1993-1997. A mortality follow-up was conducted through 2007. Standardised mortality ratios (SMRs) were calculated and Poisson regression was performed to assess mesothelioma risks. A high risk was observed for pleural mesothelioma (SMR 28.10, 95% CI 15.73-46.36) that decreased after cessation of exposure (RR 0.1; 95% CI 0.0-0.6 for > or =30 vs. <30 years after last exposure). Asbestosis was a significant risk factor for mesothelioma (RR 6.0, 95% CI 2.4-14.7). Mesothelioma mortality was still in excess in former asbestos workers although decreasing after cessation of exposure. Fibrosis was associated with subsequent malignancy.

DOI: 10.1016/j.ijheh.2009.09.001
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@article{Pesch2010CancerMI, title={Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos.}, author={B. Pesch and Dirk Taeger and Georg Johnen and Isabelle Mercedes Gross and Daniel G Weber and Monika Gube and Alice M{\"{u}ller-Lux and Evelyn Heinze and Thorsten Wiethege and Volker Neumann and Andrea Tannapfel and Hans-J{\"{u}rgen Raithel and Thomas Br{\"{u}ning and Thomas Kraus}, journal={International journal of hygiene and environmental health}, year={2010}, volume={213 1}, pages={44-51} }