Cancer models, genomic instability and somatic cellular Darwinian evolution

@inproceedings{Little2009CancerMG,
  title={Cancer models, genomic instability and somatic cellular Darwinian evolution},
  author={Mark P. Little},
  booktitle={Biology Direct},
  year={2009}
}
The biology of cancer is critically reviewed and evidence adduced that its development can be modelled as a somatic cellular Darwinian evolutionary process. The evidence for involvement of genomic instability (GI) is also reviewed. A variety of quasi-mechanistic models of carcinogenesis are reviewed, all based on this somatic Darwinian evolutionary hypothesis; in particular, the multi-stage model of Armitage and Doll (Br. J. Cancer 1954:8;1-12), the two-mutation model of Moolgavkar, Venzon, and… CONTINUE READING

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References

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The Biology of Cancer

  • RA Weinberg
  • New York, NY: Garland Science
  • 2007
Highly Influential
11 Excerpts

XW: A new stochastic and state space model of human colon cancer incorporating multiple pathways

  • WY Tan, Tan
  • Biology Direct
  • 2010
Highly Influential
12 Excerpts

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