Cancer models, genomic instability and somatic cellular Darwinian evolution

  title={Cancer models, genomic instability and somatic cellular Darwinian evolution},
  author={Mark P. Little},
  booktitle={Biology Direct},
The biology of cancer is critically reviewed and evidence adduced that its development can be modelled as a somatic cellular Darwinian evolutionary process. The evidence for involvement of genomic instability (GI) is also reviewed. A variety of quasi-mechanistic models of carcinogenesis are reviewed, all based on this somatic Darwinian evolutionary hypothesis; in particular, the multi-stage model of Armitage and Doll (Br. J. Cancer 1954:8;1-12), the two-mutation model of Moolgavkar, Venzon, and… CONTINUE READING


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