Cancer metastasis is selective or random depending on the parent tumour population

@article{Talmadge1982CancerMI,
  title={Cancer metastasis is selective or random depending on the parent tumour population},
  author={James E Talmadge and Isaiah Josh Fidler},
  journal={Nature},
  year={1982},
  volume={297},
  pages={593-594}
}
The issue of whether metastases result from the random survival of cells released from the primary tumour or from the selective growth of specialized subpopulations of cells having properties that allow them to complete the metastatic process is important to our understanding of tumour biology1,2. Previous studies have provided indirect evidence that the process of metastasis favours the survival of cells having a metastatic phenotype(s)3–8. Direct evidence that the process is selective would… CONTINUE READING

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