Cancer-linked DNA hypomethylation and its relationship to hypermethylation.

  title={Cancer-linked DNA hypomethylation and its relationship to hypermethylation.},
  author={M. Ehrlich},
  journal={Current topics in microbiology and immunology},
  • M. Ehrlich
  • Published 2006 in Current topics in microbiology and immunology
It is not surprising that cancer, a kind of derangement of development, hijacks DNA methylation, which is necessary for normal mammalian embryogenesis. Both decreases and increases in DNA methylation are a frequent characteristic of a wide variety of cancers. There is often more hypomethylation than hypermethylation of DNA during carcinogenesis, leading to a net decrease in the genomic 5-methylcytosine content. Although the exact methylation changes between different cancers of the same type… CONTINUE READING