Cancer-induced bone pain: Mechanisms and models.

  title={Cancer-induced bone pain: Mechanisms and models.},
  author={Alysia N Lozano-Ondoua and Ashley M Symons-Liguori and Todd W. Vanderah},
  journal={Neuroscience letters},
  volume={557 Pt A},
Cancerous cells can originate in a number of different tissues such as prostate, breast and lung, but often go undetected and are non-painful. Many types of cancers have a propensity to metastasize to the bone microenvironment first. Tumor burden within the bone causes excruciating breakthrough pain with properties of ongoing pain that is inadequately managed with current analgesics. Part of this failure is due to the poor understanding of the etiology of cancer pain. Animal models of cancer… CONTINUE READING
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