Cancer immunotherapeutic potential of novel small molecule TLR7 and TLR8 agonists.

@article{Hamm2009CancerIP,
  title={Cancer immunotherapeutic potential of novel small molecule TLR7 and TLR8 agonists.},
  author={Svetlana Hamm and Sandra Rath and Susanne Michel and Roland Baumgartner},
  journal={Journal of immunotoxicology},
  year={2009},
  volume={6 4},
  pages={257-65}
}
Toll-like receptor (TLR)-mediated signaling is proposed as an immunotherapeutic target against tumorigenesis. Natural killer (NK) cells play a critical role in host defense against tumors. Specifically, formation of tumor metastasis in various organs can be suppressed by the local activity of NK cells. In this study, we present a novel TLR7 agonist (termed SC-1) that induces pro-inflammatory cytokines in human blood cells, activates NK cell function, and is highly efficient in preventing lung… CONTINUE READING
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