Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.

  title={Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.},
  author={Robert D Schreiber and L. John Old and Mark J Smyth},
  volume={331 6024},
Understanding how the immune system affects cancer development and progression has been one of the most challenging questions in immunology. Research over the past two decades has helped explain why the answer to this question has evaded us for so long. We now appreciate that the immune system plays a dual role in cancer: It can not only suppress tumor growth by destroying cancer cells or inhibiting their outgrowth but also promote tumor progression either by selecting for tumor cells that are… CONTINUE READING
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Kershaw for invaluable advice and contributions to this review

M.H.M.D. Vesely
VOL 331 SCIENCE • 1203

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