Cancer heterogeneity: origins and implications for genetic association studies.


Genetic association studies have become standard approaches to characterize the genetic and epigenetic variability associated with cancer development, including predispositions and mutations. However, the bewildering genetic and phenotypic heterogeneity inherent in cancer both magnifies the conceptual and methodological problems associated with these… (More)
DOI: 10.1016/j.tig.2012.07.001


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