Cancer genomics: technology, discovery, and translation.

  title={Cancer genomics: technology, discovery, and translation.},
  author={Ben Tran and Janet E. Dancey and Suzanne Kamel-Reid and John D. McPherson and Philippe L B{\'e}dard and Andrew M. K. Brown and Tong Zhang and Patricia Shaw and Nicole Onetto and Lincoln D. Stein and Thomas J. Hudson and Benjamin G Neel and Lillian L. Siu},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={30 6},
In recent years, the increasing awareness that somatic mutations and other genetic aberrations drive human malignancies has led us within reach of personalized cancer medicine (PCM). The implementation of PCM is based on the following premises: genetic aberrations exist in human malignancies; a subset of these aberrations drive oncogenesis and tumor biology; these aberrations are actionable (defined as having the potential to affect management recommendations based on diagnostic, prognostic… CONTINUE READING
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