Cancer genome landscapes.

@article{Vogelstein2013CancerGL,
  title={Cancer genome landscapes.},
  author={Bert Vogelstein and Nikolaos G. Papadopoulos and Victor E. Velculescu and Shibin Zhou and Luis A Diaz and Kenneth W Kinzler},
  journal={Science},
  year={2013},
  volume={339 6127},
  pages={
          1546-58
        }
}
Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a small number of "mountains" (genes altered in a high percentage of tumors) and a much larger number of "hills" (genes altered infrequently). To date, these studies have revealed ~140 genes that, when altered by intragenic mutations, can promote or "drive" tumorigenesis. A typical tumor contains two to eight of these… CONTINUE READING

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