Cancer genetics and genomics of human FOX family genes.

  title={Cancer genetics and genomics of human FOX family genes.},
  author={Masuko Katoh and Maki Igarashi and Hirokazu Fukuda and Hitoshi Nakagama},
  journal={Cancer letters},
  volume={328 2},
Forkhead-box (FOX) family proteins, involved in cell growth and differentiation as well as embryogenesis and longevity, are DNA-binding proteins regulating transcription and DNA repair. The focus of this review is on the mechanisms of FOX-related human carcinogenesis. FOXA1 is overexpressed as a result of gene amplification in lung cancer, esophageal cancer… CONTINUE READING