Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector.

@article{Yoon1998CancerGT,
  title={Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector.},
  author={Sam S Yoon and Nancy M. Carroll and E. A. Chiocca and Kenneth K Tanabe},
  journal={Annals of surgery},
  year={1998},
  volume={228 3},
  pages={366-74}
}
OBJECTIVE The authors investigate the efficacy of hrR3, a viral vector derived from herpes simplex virus type 1 (HSV 1), in destroying colon carcinoma cells in vitro and in vivo. The effect of adding the prodrug ganciclovir in combination with hrR3 infection also is assessed. SUMMARY BACKGROUND DATA Most cancer gene therapy strategies use viral vectors that are incapable of replication. The HSV 1 vector hrR3 is capable of replication, and its replication is cytotoxic to cells. hrR3 also… CONTINUE READING

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