Cancer gene therapy: A bystander effect using the gap junctional pathway

@article{Pitts1994CancerGT,
  title={Cancer gene therapy: A bystander effect using the gap junctional pathway},
  author={John D. Pitts},
  journal={Molecular Carcinogenesis},
  year={1994},
  volume={11}
}
  • J. Pitts
  • Published 1 November 1994
  • Biology
  • Molecular Carcinogenesis

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TLDR
It is suggested that gemcitabine treatment could be more efficient for treating solid tumors that display gap junctions, and the presence of these cellular channels could be used to predict the responsiveness to this nucleoside analogue therapy.

Bystander effect in the adenovirus-mediated wild-type p53 gene therapy model of human squamous cell carcinoma of the head and neck.

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Radiation-Induced Bystander Effect can be Transmitted Through Exosomes Using miRNAs as Effector Molecules

TLDR
After investigating the field of RIBE, it is important to understand the mechanisms and consequences of biological effects as well as the role of exosomes and exosomal miRNAs therein, from different sources and under different circumstances, respectively.

Connexins in cancer: bridging the gap to the clinic

TLDR
The current understanding of the role of connexins and gap junctions in cancer is reviewed, with particular focus on the recent progress made in determining their prognostic and therapeutic potential.

University of Groningen Ovarian cancer gene therapy

TLDR
This review provides an overview of existing gene therapy strategies for ovarian carcinoma and attempts to develop strategies for their targeted delivery to ovarian carcinomas to increase the therapeutic index of gene therapy.

Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells

TLDR
It is demonstrated that HA-conjugated liposomes encapsulating GEM show promise for the therapy of breast cancer in vitro and in a xenograft model by targeting the BCSCs.

Gap junctions and cancer: communicating for 50 years

TLDR
This Timeline article highlights the milestones connecting gap junctions to cancer, and underscores important unanswered questions, controversies and therapeutic opportunities in the field.
...

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