Cancer gene discovery using the Sleeping Beauty transposon.

@article{Starr2005CancerGD,
  title={Cancer gene discovery using the Sleeping Beauty transposon.},
  author={Timothy K. Starr and David A. Largaespada},
  journal={Cell cycle},
  year={2005},
  volume={4 12},
  pages={1744-8}
}
Epidemiological and molecular data support the hypothesis that cancer results from a series of acquired somatic mutations. Discovering the initial mutations required for oncogenesis has long been a goal of cancer research. To date, the majority of causative mutations have been identified based on their ability to act in a dominant fashion and/or because they are activated by chromosomal translocations. Forward genetic screens are necessary for unbiased discovery of the remaining unknown… CONTINUE READING

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