Cancer exosomes trigger fibroblast to myofibroblast differentiation.

@article{Webber2010CancerET,
  title={Cancer exosomes trigger fibroblast to myofibroblast differentiation.},
  author={Jason Paul Webber and Robert G. Steadman and Malcolm David Mason and Zsuzsanna Tabi and Aled Clayton},
  journal={Cancer research},
  year={2010},
  volume={70 23},
  pages={
          9621-30
        }
}
There is a growing interest in the cell-cell communication roles in cancer mediated by secreted vesicles termed exosomes. In this study, we examined whether exosomes produced by cancer cells could transmit information to normal stromal fibroblasts and trigger a cellular response. We found that some cancer-derived exosomes could trigger elevated α-smooth muscle actin expression and other changes consistent with the process of fibroblast differentiation into myofibroblasts. We show that TGF-β is… CONTINUE READING

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