Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production.

@article{Clayton2011CancerEE,
  title={Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production.},
  author={Aled Clayton and Saly Al-Taei and Jason Paul Webber and Malcolm David Mason and Zsuzsanna Tabi},
  journal={Journal of immunology},
  year={2011},
  volume={187 2},
  pages={676-83}
}
Extracellular adenosine is elevated in cancer tissue, and it negatively regulates local immune responses. Adenosine production from extracellular ATP has attracted attention as a mechanism of regulatory T cell-mediated immune regulation. In this study, we examined whether small vesicles secreted by cancer cells, called exosomes, contribute to extracellular… CONTINUE READING