Cancer esearch apeutics , Targets , and Chemical Biology MT-Independent Temozolomide Resistance in Pediatric blastoma Cells Associated with a PI 3-Kinase – Mediated R / Stem Cell Gene Signature

@inproceedings{Gaspar2010CancerEA,
  title={Cancer esearch apeutics , Targets , and Chemical Biology MT-Independent Temozolomide Resistance in Pediatric blastoma Cells Associated with a PI 3-Kinase – Mediated R / Stem Cell Gene Signature},
  author={lie Gaspar and Lynley Marshall and Lara Perryman and Dorine A. Bax and Suzanne E. Little and Viana-Pereira and Swee Y. Sharp and Gilles Vassal and Andrew D. J. Pearson and . Reis and Darren Hargrave and Paul Workman and Chris Jones},
  year={2010}
}
Download sitivity to temozolomide is restricted to a subset of glioblastoma patients, with the major determinant of nce being a lack of promoter methylation of the gene encoding the repair protein DNA methyltransferGMT, although other mechanisms are thought to be active. There are, however, limited preclinical data in systems derived from pediatric glioma patients. We screened a series of cell lines for temozolomide efficacy , and investigated the differential mechanisms of resistance involved… CONTINUE READING
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