Cancer epigenetics.

  title={Cancer epigenetics.},
  author={Wendell W. Weber},
  journal={Progress in molecular biology and translational science},
  • W. Weber
  • Published 2010
  • Biology
  • Progress in molecular biology and translational science

Feedback networks between microRNAs and epigenetic modifications in urological tumors

An overview of microRNA-epigenetic circuits acting in urological tumors is presented, which could provide new approaches for the development of novel individualized therapies, which are adjusted to the molecular pattern of a tumor.

Epigenetics and chemoresistance in colorectal cancer: an opportunity for treatment tailoring and novel therapeutic strategies.

  • F. CreaS. Nobili E. Mini
  • Biology
    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
  • 2011

Review: Advances in methodology of DNA methylation assay

This work summerize some novel methods mainly based on chemical modification and analytic methods in DNA detection based on essential roles of DNA methylation in the living system.

Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development

It is demonstrated that genome-wide cytosine methylation patterns of healthy and chronic kidney disease tubule samples obtained from patients show significant differences, raising the possibility that epigenetic dysregulation plays a role in chronic kidneys disease development via influencing core pro-fibrotic pathways and can aid the development of novel biomarkers and future therapeutics.

Epigenetic Risks of Medically Assisted Reproduction

The aim of this review was to present evidence from the literature regarding epigenetic errors linked to assisted reproduction treatments and their consequences on the conceived children and provide an overview of disease risk associated with epigenetic or imprinting alterations in children born via ART.

Contemporary Use of ICSI and Epigenetic Risks to Future Generations

Data concerning the health of ICSI children over the past thirty years seems to support the notion that there might be an increased risk of epigenetic disorders, congenital malformations, chromosomal alterations, and subfertility in babies born following ICSi compared to naturally conceived children.

Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions

A critical appraisal of the current state of PTE research with an emphasis on experimental models, molecular mechanisms of post-traumatic epileptogenesis, potential biomarkers, and the burden of Pte-associated comorbidities is described.

Epigenetics and Reproductive Medicine

Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?

From a cancer research perspective, there has been a rediscovery that a switch in cell metabolism is critical for cancer progression but this is set within the metabolic status of the host, which implies that the seeds may be plentiful but they only germinate in the right soil.



Epigenetics in human disease and prospects for epigenetic therapy

Great potential lies in the development of ‘epigenetic therapies’ — several inhibitors of enzymes controlling epigenetic modifications, specifically DNA methyltransferases and histone deacetylases, have shown promising anti-tumorigenic effects for some malignancies.

Cancer-epigenetics comes of age

Current mechanistic understanding of the role of DNA methylation in malignant transformation is reviewed, and it is suggested Knudson's two–hit hypothesis should be expanded to include epigenetic mechanisms of gene inactivation.

Cancer epigenomics: DNA methylomes and histone-modification maps

It is time to 'upgrade' cancer epigenetics research and put together an ambitious plan to tackle the many unanswered questions in this field using epigenomics approaches.

The epigenetic progenitor origin of human cancer

This work suggests that non-neoplastic but epigenetically disrupted stem/progenitor cells might be a crucial target for cancer risk assessment and chemoprevention.

The Clinical Application of Targeting Cancer through Histone Acetylation and Hypomethylation

Epigenetic changes, heritable traits that are mediated by changes in DNA other than nucleotide sequences, play an important role in gene expression and up-regulation of genes important to prevent or reverse the malignant phenotype has become a new therapeutic target in cancer treatment.

How epigenetics can explain human metastasis: A new role for microRNAs

In this review, the latest studies relating cancer epigenetics and metastasis are analyzed, and the importance of miRNAs and their epigenetic regulation in tumoral progression is emphasized.

Cancer genetics of epigenetic genes.

The evidence that these genes can be targeted by mutations and expression changes in human cancers is reviewed.

Epigenetics in cancer: Targeting chromatin modifications

A number of compounds targeting enzymes that regulate histone acetylation, histone methylation, and DNA methylation have been developed as epigenetic therapies, with some demonstrating efficacy in hematological malignancies and solid tumors.